Targeted ablation of IKK2 improves skeletal muscle strength, maintains mass, and promotes regeneration
J. Clin. Invest. Foteini Mourkioti, et al. 116:2945 doi:10.1172/JCI28721 [
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Figure 5IKK2 muscle depletion protects fiber size and maintains fiber type. (
A and
B) Representative images of H&E-stained atrophied muscle 28 days after denervation. Note the absence of angular atrophic fibers and the nuclear accumulation in
Ikk2mko denervated muscles (
C) Histogram (frequency distribution of fiber CSA) shows the maintenance of fiber size in
Ikk2mko gastrocnemius (white bars) compared with the control atrophied muscles (black bars). (
D and
E) Representative images of NADH staining that mark slow fibers with dark blue (red arrows) and intermediate fibers with light blue (purple arrows). (
F) Fiber-type distribution in denervated soleus muscles: 37.5% decrease in slow fibers in control muscles, which become intermediate. Note the maintenance of fiber-type distribution in
Ikk2mko denervated soleus.
