Targeted ablation of IKK2 improves skeletal muscle strength, maintains mass, and promotes regeneration
J. Clin. Invest. Foteini Mourkioti, et al. 116:2945 doi:10.1172/JCI28721 [Go to this article.]

Figure 3
IKK2 muscle deletion improves muscle strength. (A) Increased specific twitch force of Ikk2^mko EDL in comparison with control EDL from littermates. (B) Lower maximum specific tetanic force of EDL in control (n = 15) versus Ikk2^mko animals (n = 11). (C) Time to exhaustion in treadmill test; control mice (n = 5) displayed a significantly lower performance than Ikk2^mko mice (n = 5). *Mean values differ significantly from those of control (P < 0.05).