Mutations within Sox2/SOX2 are associated with abnormalities in the hypothalamo-pituitary-gonadal axis in mice and humans
J. Clin. Invest. Daniel Kelberman, et al. 116:2442 doi:10.1172/JCI28658 [Go to this article.]

Figure 3
Testes morphology of Sox2^+/– males. (A) Testis of an 11-month-old wild-type mouse. (B) Histological analysis of the testis shown in A. All the different stages of germ cells are present within the seminiferous tubules. (C) Testis of an 11-month-old Sox2^+/– mouse showing reduced size and white opaque patches, indicative of sperm blockage. This was confirmed by histological analysis (D), where aberrant tubules were seen that contained very large numbers of mature sperm only, instead of a range of spermatogenic stages (arrow). The somatic cells also looked abnormal in these tubules. Scale bars: 1,260 μm (A and C); 55 μm (B); 42 μm (D).