Mutations within Sox2/SOX2 are associated with abnormalities in the hypothalamo-pituitary-gonadal axis in mice and humans
J. Clin. Invest. Daniel Kelberman, et al. 116:2442 doi:10.1172/JCI28658 [Go to this article.]

Figure 2
Sox2 expression and abnormal morphogenesis of the pituitary in Sox2 heterozygotes. (A) Sagittal section of an 11.5-dpc wild-type embryo hybridized to Sox2, showing expression in both the CNS and Rathke’s pouch. (B and C) Sagittal sections of 12.5 dpc wild-type (B) and Sox2 heterozygous (C) embryos, showing bifurcation of the pouch in the mutant embryo. (D and E) Pituitary transverse sections of 5-week-old wild-type (D) and Sox2 heterozygous mice (E). Note the presence of an extra cleft in the Sox2 heterozygous pituitary (arrow). HYP, presumptive hypothalamus; RP, Rathke’s pouch. Scale bars: 0.1 mm.