Chronic activation of the prostaglandin receptor EP4 promotes hyaluronan-mediated neointimal formation in the ductus arteriosus
J. Clin. Invest. Utako Yokoyama, et al. 116:3026 doi:10.1172/JCI28639 [
Go to this article.]
Figure 1The expression of prostanoid receptors in the rat DA and aorta during development. Quantitative RT-PCR analyses of EP isoforms (EP2, EP3, and EP4) and other prostanoid receptors (PGF
2α receptor [Ptgfr], PGI
2 receptor [IP], and thromboxane A
2 receptor [Tbxa2r]) in the rat DA and aorta. The expression of EP4 mRNA was significantly higher in DA than in the aorta (upper right). The expression level of EP4 mRNA was maximal at E21 in the DA. *
P < 0.05, **
P < 0.01,
#P < 0.001.
