Fatty acid amide hydrolase deficiency limits early pregnancy events
J. Clin. Invest. Haibin Wang, et al. 116:2122 doi:10.1172/JCI28621 [Go to this article.]

Figure 3
FAAH deficiency increases oviductal anandamide levels, leading to tubal retention and retarded embryo development in mice. (A) Oviductal levels of anandamide were significantly increased in Faah^–/– mice during early pregnancy. (B) Number of mice with oviductal embryo retention per total number of mice examined on day 4 of pregnancy. (C) Percentage of embryos recovered from oviducts or uteri. (D and E) Asynchronous development of embryos in Faah^–/– mice. The results show that higher levels of oviductal anandamide are correlated with oviductal retention of embryos and retarded embryo development in Faah^–/– mice. Statistical analysis was performed using unpaired 1-tailed Student’s t test (*P < 0.05). Scale bar: 100 μm. Mo, morula; Bl, blastocyst; M, male; F, female.