Aberrant accumulation of PTTG1 induced by a mutated thyroid hormone β receptor inhibits mitotic progression
J. Clin. Invest. Hao Ying, et al. 116:2972 doi:10.1172/JCI28598 [
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Figure 1Increased abundance of PTTG1 in metastatic thyroid carcinomas of
TRβ
PV/PV mice.
Shown are thyroids from wild-type mice (
A and
B), thyroids from
TRβ
PV/PV mice (
C and
D), and lung metastasis from
TRβ
PV/PV mice (
E and
F) stained by H&E (
A,
C, and
E) and immunostained by anti-PTTG1 antibody (
B,
D, and
F) as described in Methods.