Selective tyrosine kinase inhibition by imatinib mesylate for the treatment of autoimmune arthritis
J. Clin. Invest. Ricardo T. Paniagua, et al. 116:2633 doi:10.1172/JCI28546 [Go to this article.]

Figure 2
Imatinib reduces synovitis, pannus formation, and joint erosions in CIA. (A) Representative H&E-stained joint tissue sections from DBA/1 mice from a CIA prevention study. (B and C) Histopathological scores of inflammation, pannus formation, and bone and cartilage erosions in DBA/1 mice with CIA in the prevention (B; PBS, n = 8; 33 mg/kg imatinib, n = 8; 100 mg/kg imatinib, n = 8) and treatment (C; PBS, n = 8; 33 mg/kg imatinib, n = 8; 100 mg/kg imatinib, n = 8) studies. Values are mean ± SEM. *P < 0.05, **P < 0.01 compared with PBS-treated group.