Muscular atrophy of caveolin-3–deficient mice is rescued by myostatin inhibition
J. Clin. Invest. Yutaka Ohsawa, et al. 116:2924 doi:10.1172/JCI28520 [
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Figure 4Myostatin inhibition reverses hypoplasia and hypotrophy and enhances muscle strength in mutant caveolin-3–Tg mice. (
A) Histological and immunohistochemical analyses of TA muscle from 10-week-old mice. LAMα2, laminin α2. Scale bar: 50 μm. (
B) Distribution of single myofiber area of TA muscle from mice at 10 weeks of age (
n = 5; 250 myofibers measured for each mouse). (
C) Total numbers of myofibers of TA muscle from mice at 10 weeks of age. Data are expressed as mean ± SD (
n = 5). *
P < 0.05. (
D) Peak force measurements (g) of grip strength of mice at 4, 8, 12, and 16 weeks of age. Data are expressed as mean ± SD (
n = 7). *
P < 0.05.
