Muscular atrophy of caveolin-3–deficient mice is rescued by myostatin inhibition
J. Clin. Invest. Yutaka Ohsawa, et al. 116:2924 doi:10.1172/JCI28520 [Go to this article.]

Figure 3
Myostatin inhibition reverses muscular atrophy of mutant caveolin-3–Tg mice. (A) Comparison of body weight of mice at 3, 4, 6, 8, 10, 12, and 16 weeks of age. Data are expressed as mean ± SD (n = 7). *P < 0.05. (B) Appearance of skinned hind limbs from 10-week-old mice of the 4 distinct genotypes. Scale bar: 5 mm. (C) Axial computed tomographic scans of the center of distal hind limbs in 10-week-old mice. Scale bar: 5 mm. Mutant CAV-3 Tg, CAV-3^P104L; mutant MSTN Tg, MSTN^Pro; double Tg, CAV-3^P104L/MSTN^Pro.