Proteinuria precedes podocyte abnormalities inLamb2–/–
mice, implicating the glomerular basement membrane as an albumin barrier
J. Clin. Invest. George Jarad, et al. 116:2272 doi:10.1172/JCI28414 [
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Figure 6
Normal GBM permeability to ferritin in
Cd2ap–/–
mice.
Ferritin injections were performed in
Cd2ap–/– and control littermate mice. (
A and
B) Total numbers of ferritin particles in the GBM at 1 and 2 hours after injection were similar in nephrotic
Cd2ap–/– mice and their normal littermates at P21. However, subepithelial ferritin particle numbers were lower in the mutant, despite the albuminuria. (
C–
F) Representative electron micrographs showing ferritin particles in the GBM of P21 normal (
C and
D) and
Cd2ap–/– (
E and
F) mice.
D and
F are higher magnifications of
C and
E, respectively. Scale bars: 125 nm.
