C5a and Fcγ receptors:
a mutual admiration society
J. Clin. Invest. John P. Atkinson, et al. 116:304 doi:10.1172/JCI27759 [
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Figure 1The interactions among C5a and IgG and their receptors. Humoral autoimmunity is illustrated. An IgG response has been made to an antigen on the surface of erythrocytes. IgG binds to this antigen to form immune complexes. Such immune complexes can both interact with FcγR and activate the complement system. The FcγR signals the cell to increase C5 synthesis, resulting in more C5a, which in turn feeds back through its receptor to upregulate FcγR expression.
