Cardiac autophagy is a maladaptive response to hemodynamic stress
J. Clin. Invest. Hongxin Zhu, et al. 117:1782 doi:10.1172/JCI27523 [Go to this article.]

Figure 4
Pressure overload induces apoptosis in proximal aorta but not in LVs. (A) Rare TUNEL-positive figures (pink circles) are detected in ventricular myocardium from sham-operated or sTAB hearts (basal septum) whereas a significantly increased signal is detected in aorta. Scale bar: 10 μm. (B) Microscopic fields (10–15 per section), each containing approximately 800 myocytes, were evaluated by TUNEL staining (n = 30–45 fields from each of 3 mice at each time point) in C57BL/6 mice. P = NS for each time point compared with sham. (C) DNA laddering (arrows) indicative of apoptosis in proximal aortic tissue (Ao), but not LVs, in animals subjected to sTAB.