NF-κB regulation of endothelial cell function during LPS-induced toxemia and cancer
J. Clin. Invest. Tatiana Kisseleva, et al. 116:2955 doi:10.1172/JCI27392 [Go to this article.]

Figure 2
Tie-Tg mice exhibit increased sensitivity to LPS-induced toxemia. (A) Transgenic mice (Tie-Tg lines 2 and 4) and littermate control WT mice were injected with LPS (8 μg/g, i.v.) and evaluated for survival by a Kaplan-Meier plot. Similar results were obtained for Tie-Tg lines 1 and 3 (data not shown). (B) Matched H&E- and TUNEL-stained paraffin-embedded tissues (spleen, liver, and lung) from transgenic (line 2) and WT littermate control mice 18 hours after PBS or LPS (2 μg/g weight) injection, as visualized with an ×20 objective. TUNEL-positive cells are revealed by brown stain. Similar results were obtained for Tie-Tg line 4.