Local InsP₃-dependent perinuclear Ca²⁺ signaling in cardiac myocyte excitation-transcription coupling
J. Clin. Invest. Xu Wu, et al. 116:675 doi:10.1172/JCI27374 [Go to this article.]

Figure 1
Working hypothesis. ET-1 induces HDAC5 nuclear export via a pathway involving InsP₃ (IP₃) and InsP₃R (IP₃R) with associated CaM and CaMKII, leading to HDAC5 phosphorylation and nuclear export, thereby derepressing the transcription factor MEF2 (see text for additional details). Hyp, hypertrophy.