Intestinal ABCA1 directly contributes to HDL biogenesis in vivo
J. Clin. Invest. Liam R. Brunham, et al. 116:1052 doi:10.1172/JCI27352 [Go to this article.]

Figure 5
Intestinal cholesterol transport in mice lacking intestinal ABCA1. (A) Appearance of [³H]cholesterol in whole-plasma, HDL, and non-HDL fractions after 2 hours. Mice were gavaged with 0.2 μCi of [³H]cholesterol, and the appearance of the tracer was assessed after 2 hours. (B) [³H]cholesterol in liver 2 hours after oral gavage. (C) [³H]cholesterol in small intestine 2 hours after oral gavage. The small intestine was rinsed with PBS to remove luminal contents. (D) Fractional cholesterol absorption determined by fecal dual-isotope method. n = 6 mice per group. *P < 0.05.