Trans -cyclopropanation of mycolic acids on trehalose dimycolate suppresses Mycobacterium tuberculosis –induced inflammation and virulence
J. Clin. Invest. Vivek Rao, et al. 116:1660 doi:10.1172/JCI27335 [Go to this article.]

Figure 4
cmaA2-dependent extractable lipid modification suppresses M. tuberculosis –induced macrophage activation. Bone marrow–derived macrophages from BALB/C mice were left uninfected (con), or infected with WT M. tuberculosis or ΔcmaA2 mutant M. tuberculosis (native), delipidated bacteria (delip), delipidated bacteria reconstituted with self lipids (delip + self), or delipidated and reconstituted with lipids from the opposite strain (delip + opposite). TNF-α levels were determined 24 hours after infection. Values are mean concentrations of quadruplicate wells.