Trans -cyclopropanation of mycolic acids on trehalose dimycolate suppresses Mycobacterium tuberculosis –induced inflammation and virulence
J. Clin. Invest. Vivek Rao, et al. 116:1660 doi:10.1172/JCI27335 [Go to this article.]

Figure 2
cmaA2 suppresses M. tuberculosis virulence in mice. (A) Survival kinetics of WT BALB/C mice infected via tail vein injection with 10⁶ CFUs of either WT M. tuberculosis (squares), ΔcmaA2 M. tuberculosis (circles), or the complemented ΔcmaA2 strain (triangles). (B and C) Survival kinetics of WT C57BL/6J mice infected with M. tuberculosis (squares) or ΔcmaA2 M. tuberculosis (circles) by tail vein injection (10⁵ CFUs, B) or aerosol (100 CFUs, C). (D) Survival of immunodeficient mice infected with WT (squares) and ΔcmaA2 (circles) strains. TNF-α–deficient mice (solid lines), IFN-γ–deficient mice (dotted lines), and SCID mice (dashed lines) were infected as described in Methods, and survival was recorded.