Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities
J. Clin. Invest. Tilo Grosser, et al. 116:4 doi:10.1172/JCI27291 [Go to this article.]

Figure 3
Roles of the COX isozymes in cardiovascular (A and C) and renal (B) biology. ACE, angiotensin-converting enzyme; ADP, adenosine diphosphate; aPC, activated protein C; BK, bradykinin; ecNOS, endothelial cell NOS; MBF, medullary blood flow; RAS, renin-angiotensin system; TM, thrombomodulin.