Neutrophils and their Fcγ receptors are essential in a mouse model of transfusion-related acute lung injury
J. Clin. Invest. Mark R. Looney, et al. 116:1615 doi:10.1172/JCI27238 [Go to this article.]

Figure 7
Neutrophil depletion with Gr-1 mAb protects mice from MHC I mAb–induced ALI. Mice were pretreated with either i.p. PBS or i.p. Gr-1 mAb (250 μg) and after 24 hours were given i.v. MHC I mAb and compared with mice given i.v. PBS. The Gr-1 mAb–pretreated mice had greatly attenuated excess lung water (A) and lung vascular permeability to ¹²⁵I-labeled albumin (B) compared with mice pretreated with PBS. Each data point represents an individual animal. **P < 0.01.