Neutrophils and their Fcγ receptors are essential in a mouse model of transfusion-related acute lung injury
J. Clin. Invest. Mark R. Looney, et al. 116:1615 doi:10.1172/JCI27238 [
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Figure 2MHC I mAb produces mortality and increased lung injury in nonsurvivors versus survivors. (
A) BALB/c mice given MHC I mAb (
n = 36) showed decreased survival at 2 hours compared with BALB/c mice given either isotype-matched mAb or PBS (
n = 22). **
P < 0.01, c
2 test. The MHC I mAb–challenged mice that died before 2 hours (
n = 15) had increased excess lung water (
B) and increased EVPE (
C) compared with MHC I mAb–challenged mice that survived the 2-hour experimental period (
n = 15). **
P < 0.01; *
P < 0.05.
