Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype
J. Clin. Invest. Pal Kaposi-Novak, et al. 116:1582 doi:10.1172/JCI27236 [
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Figure 6
Association between the different clinicopathological variables and the Met
+
and Met
–
HCC subsets defined by hierarchical cluster analysis of the LEC samples.
Kaplan-Meier plot (
A) and log-rank statistics demonstrate the difference in the overall survival between HCC patients from the Met
+ and from the Met
– groups. (
B and
C) Bar graphs represent vascular invasion rate (
B) and average MVD (
C) in HCC samples from Met
+ and Met
– sets. MVD was determined by quantitative analysis of CD34
+ vascular features. (
D and
E) Microscope images show CD34 staining of endothelial cells in representative samples from Met
+ (
D) and Met
– (
E) tumor sets. Pictures were taken with ×200 original magnification.