Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype
J. Clin. Invest. Pal Kaposi-Novak, et al. 116:1582 doi:10.1172/JCI27236 [Go to this article.]

Figure 5
Expression profiles of the Met-regulated genes in HCCs from the Stanford data set. (A) Hierarchical cluster analysis of mouse hepatocyte samples together with 103 HCC and 7 liver metastases from the Stanford data set. Clustering was performed with 303 common orthologous genes that showed HGF/Met–regulated expression pattern in mouse hepatocytes. Normalized log₂-transformed expression ratios are presented in a matrix where columns and rows represent individual genes and samples, respectively. (B) Dendrogram of cluster analysis shows that several HCC samples and all metastatic tumors (Met⁺ group) share a similar expression pattern with the HGF-treated control hepatocytes (WT). HCC samples in the Met^– group and Met KO hepatocytes do not share the same gene expression pattern of Met activation.