Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype
J. Clin. Invest. Pal Kaposi-Novak, et al. 116:1582 doi:10.1172/JCI27236 [Go to this article.]

Figure 4
Expression profiles of the Met-regulated genes in HCCs from the LEC data set. (A) Hierarchical cluster analysis of mouse hepatocyte samples and 139 HCCs from the LEC data set. Clustering was performed with 440 common orthologous genes that showed HGF/Met–regulated expression pattern in mouse hepatocytes. Normalized log₂-transformed expression ratios are presented in a matrix where columns and rows represent individual genes and samples, respectively. (B) Dendrogram of cluster analysis indicates the presence of an HCC subset (Met⁺ group) in which the expression pattern of Met-regulated genes is similar to that in the HGF-treated WT hepatocyte samples. HCC samples in the Met^– group and Met KO hepatocytes do not share the same gene expression pattern of Met activation. The figure also shows distribution of HCC samples between the previously described (37) worse-prognosis (cluster A) and better-prognosis (cluster B) tumor groups.