Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype
J. Clin. Invest. Pal Kaposi-Novak, et al. 116:1582 doi:10.1172/JCI27236 [Go to this article.]

Figure 2
Gene expression patterns of HGF-regulated genes in primary mouse hepatocytes. Gene expression ratios from duplicated dye-swapped hybridizations per sample were averaged before generation of the heat map. (A and B) Two matrices were constructed from normalized, log₂-transformed expression ratios of genes with permanent (A) and HGF-induced (B) expression differences between the WT and Met KO cells. Red and blue columns at the top represent triplicate WT and Met KO samples, respectively, from the consecutive treatment points (0, 0.5, 2, 12, and 24 hours). Rows represent individual genes. (C) HGF/Met–dependent genes also formed clusters with different temporal induction patterns. Bar graphs show the mean expression differences ± SEM between the WT and Met KO samples in 6 gene clusters with expression peaks at early (C1, C4), late (C3, C6), or both early and late (C2, C5) HGF treatment points. Other gene clusters displayed permanently higher expression levels either in the WT or in the Met KO samples.