HTLV-1 propels untransformed CD4⁺ lymphocytes into the cell cycle while protecting CD8⁺ cells from death
J. Clin. Invest. David Sibon, et al. 116:974 doi:10.1172/JCI27198 [Go to this article.]

Figure 1
Proviral loads (A ) and clonality (B ) of HTLV-1–positive cells in highly purified CD4⁺ CD8^– and CD4^– CD8⁺ lymphocytes from HAM/TSP patients DO45 and SI88 (see Table 1). The clonal distribution of integrated HTLV-1 sequences within the DNA of CD4⁺ and CD8⁺ cells was assessed by quadruplicate IPCR experiments as described in Methods. Numbers in parentheses represent the proportion of infected cells as evidenced by real-time quantitative PCR. M, molecular weight marker. C91PL is an HTLV-1 cell line used as positive control.