Platelets in inflammation and atherogenesis
J. Clin. Invest. Meinrad Gawaz, et al. 115:3378 doi:10.1172/JCI27196 [Go to this article.]

Figure 2
Adherent platelets inflame ECs. Firm platelet adhesion involving α_IIbβ₃ induces platelet surface exposure of P-selectin (CD62P) and release of CD40L and IL-1β, which stimulate ECs to provide an inflammatory milieu that supports proatherogenic alterations of endothelium.