Ligation of protease-activated receptor 1 enhances αv
β6
integrin–dependent TGF-β activation and promotes acute lung injury
J. Clin. Invest. R. Gisli Jenkins, et al. 116:1606 doi:10.1172/JCI27183 [
Go to this article.]
Figure 8
Par1
–/–
mice instilled with intratracheal bleomycin have reduced permeability and TGF-β
activation compared with WT control.
(
A) WT or
Par1–/– mice were instilled with saline (Sal.; white bars) or 0.05 U bleomycin (Bleo.; black bars). ELW was measured as described. Bleomycin,
n = 6; and saline,
n = 5. (
B) Quantification of nuclear localized phospho-Smad2 immunostaining in WT or
Par1–/– mice instilled with saline (white bars) or 0.05 U bleomycin (black bars). WT mice,
n = 4;
Par1–/–, bleomycin,
n = 4; and
Par1–/–, saline,
n = 3. (
C) Representative histological sections showing nuclear localized phospho-Smad2 immunostaining in the lung of WT or
Par1–/– mice. Original magnification, ×400. Values are presented as mean + SEM.
#P < 0.005,
*P < 0.05.
