Activated macrophages are essential in a murine model for T cell–mediated chronic psoriasiform skin inflammation
J. Clin. Invest. Honglin Wang, et al. 116:2105 doi:10.1172/JCI27180 [Go to this article.]

Figure 3
Reduction of the psoriasiform phenotype of affectedCD18^hypo mice by administration of etanercept. (A and B) A significant difference in the adapted PASI score appeared after treatment with etanercept (A; n = 5; ^#P = 0.0079, Student’s t test), but not after treatment with 0.9% NaCl control (B; n = 3; P = 0.6514, Student’s t test). (C–E) Significantly reduced numbers of macrophages in skin DLNs of affected CD18^hypo mice treated with etanercept (C) were observed after 30 days compared with controls (D and E). (F–H) Decreased numbers of MHCII⁺ cells in skin DLNs of affected CD18^hypo mice treated with etanercept (F) were detected after 30 days compared with controls (G and H). M₁, MHCII^– cells; M₂, MHCII⁺ cells. **P < 0.01, Student’s t test. (I and J) Decreased expression of TNF-α (red) was observed in the skin of affected CD18^hypo mice treated with etanercept after 30 days (I) compared with controls (J). Cell nuclei were stained with DAPI (blue). (K and L) Reduced numbers of F4/80⁺ macrophages (green) were observed in the skin of affected CD18^hypo mice treated with etanercept after 30 days (K) compared with controls (L). Cell nuclei (red) were counterstained with propidium iodide. Original magnification, ×20.