Pathogenic role for skin macrophages in a mouse model of keratinocyte-induced psoriasis-like skin inflammation
J. Clin. Invest. Athanasios Stratis, et al. 116:2094 doi:10.1172/JCI27179 [Go to this article.]

Figure 5
Targeted deletion of CD18 prevents granulocyte migration into the skin of K14-Cre-IKK2^fl/fl mice. (A) Results of white blood cell counting from blood smears of 3 K14-Cre-IKK2^fl/fl mice and 2 control mice. Note relative increase in numbers of neutrophils (stabs and polymorphonuclear granulocytes) and relative decrease in numbers of lymphocytes. (B and C) Light microscopic images of chloroacetate esterase–stained, paraffin-embedded skin sections from CD18^+/– K14-Cre-IKK2^fl/fl mice (B) and CD18^–/– K14-Cre-IKK2^fl/fl mice (C). Granulocytes are stained red (arrow). Scale bar: 50 μm. (D) Results of counting of chloroacetate esterase–positive granulocytes in skin sections from 8 CD18^–/– K14-Cre-IKK2^fl/fl mice and 6 CD18^+/+ or CD18^+/– K14-Cre-IKK2^fl/fl mice. Bars represent means of 10 fields for each mouse ± SD.