Pathogenic role for skin macrophages in a mouse model of keratinocyte-induced psoriasis-like skin inflammation
J. Clin. Invest. Athanasios Stratis, et al. 116:2094 doi:10.1172/JCI27179 [Go to this article.]

Figure 4
Injection of clodronate liposomes normalizes epidermal differentiation and prevents migration of immune cells. Immunostainings of paraffin-embedded skin sections with antibodies against the epidermal differentiation markers K14, K10, loricrin, and filaggrin (Fil) or of frozen skin with antibodies against the immune cell markers GR-1 for granulocytes and CD3 for T lymphocytes. Skin samples were obtained at P7 from K14-Cre-IKK2^fl/fl mice injected with control liposomes (left panels), clodronate liposomes (center panels), from uninjected control mice (right panels). Indicated markers are stained green, and nuclei are stained red. Scale bar: 40 μm.