Pathogenic role for skin macrophages in a mouse model of keratinocyte-induced psoriasis-like skin inflammation
J. Clin. Invest. Athanasios Stratis, et al. 116:2094 doi:10.1172/JCI27179 [Go to this article.]

Figure 3
Improvement of the psoriasis-like skin phenotype after injection of clodronate liposomes. Light microscopic images of paraffin-embedded skin sections (top 3 panels) and confocal images of cryostat skin sections (bottom 6 panels) from control mice and K14-Cre-IKK2^fl/fl mice with clodronate or control liposomes injected as indicated. Control mice were not injected. Sections in the upper panels are stained H&E. Immunostainings in the middle and lower panels are against F4/80 and phosphorylated STAT3 (Phospho-STAT3), respectively (green). Nuclei are shown in red. White dotted line indicates the position of the epidermal basement membrane. Scale bar: 100 mm (H&E); 40 μm (immunostaining).