Pathogenic role for skin macrophages in a mouse model of keratinocyte-induced psoriasis-like skin inflammation
J. Clin. Invest. Athanasios Stratis, et al. 116:2094 doi:10.1172/JCI27179 [Go to this article.]

Figure 1
Improvement of psoriasis-like skin disease in K14-Cre-IKK2^fl/fl mice by administration of huTNFR:Fc. Light microscopic and confocal images of paraffin-embedded skin sections (H&E, K14, K10, and loricrin [Lor]) and confocal images of cryostat skin sections (CD3, GR-1, F4/80) obtained at P7 from K14-Cre-IKK2^fl/fl mice injected with 20 μg per mouse of huTNFR:Fc (left panels) or human IgG (right panels). Top 2 panels are stained with H&E. For immunostainings, indicated markers are stained green, and nuclei are stained red. Scale bar: 100 μm (H&E); 40 μm (immunostaining).