Endothelial cell–restricted disruption of FoxM1 impairs endothelial repair following LPS-induced vascular injury
J. Clin. Invest. You-Yang Zhao, et al. 116:2333 doi:10.1172/JCI27154 [Go to this article.]

Figure 5
Increased mortality in FoxM1 CKO mice following LPS challenge. (A) Survival rate following LPS challenge. Mice were challenged i.p. with 12 mg/kg BW of LPS and housed under normal conditions. Approximately 70% of the FoxM1 CKO mice died from day 2 to day 4 after LPS challenge whereas only about 10% of WT mice died in this same period. Differences in the survival rates between the WT and CKO groups after LPS challenge were significant by Peto-Peto-Wilcoxon test. n = 11 mice per group. *P < 0.001. (B) Graphic representation of development of lung edema in FoxM1 CKO mice following LPS challenge (12 mg/kg). Lungs were collected either at 48 hours after LPS challenge (WT and CKO) or in some mice at day 2 just prior to their deaths (CKO-D). Data are expressed as mean ± SD. n = 3–5, ^#P < 0.05 versus WT; ^##P < 0.01 versus WT.