Insulin’s direct effects on the liver dominate the control of hepatic glucose production
J. Clin. Invest. Dale S. Edgerton, et al. 116:521 doi:10.1172/JCI27073 [Go to this article.]

Figure 2
Arterial and hepatic sinusoidal plasma glucagon levels in 18-hour-fasted conscious dogs during the basal (–40 to 0 minutes) and experimental (0–180 minutes) periods. Basal insulin infusion either continued into the portal vein (circles) or was switched to a peripheral vein (triangles) between 0 and 180 minutes. Mean ± SEM.