Thrombus formation in vivo
J. Clin. Invest. Bruce Furie, et al. 115:3355 doi:10.1172/JCI26987 [
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Figure 2Model of P-selectin/PSGL-1–mediated tissue factor accumulation during thrombus formation. (
A) Leukocyte microparticles (red) circulate constitutively in the blood under resting conditions. These microparticles express tissue factor (TF) and PSGL-1 on their surface. (
B) Vessel wall tissue factor is expressed in response to laser-induced injury, leading to platelet activation and the subsequent expression of P-selectin on the stimulated platelets incorporated into the developing thrombus (initiation phase). (
C) Blood-borne tissue factor associated with microparticles accumulates on the platelet thrombus through the binding of platelet P-selectin and microparticle PSGL-1. (
D) Concentration of blood-borne tissue factor into the thrombus initiates thrombin generation and fibrin clot propagation within the thrombus (propagation phase).
