Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice
J. Clin. Invest. Shino Niki, et al. 116:1292 doi:10.1172/JCI26971 [Go to this article.]

Figure 1
Growth abnormalities and pancreatic atrophy in Aire-deficient NOD mice. (A) Body weights of individual female (circles) and male (squares) Aire-sufficient (open symbols) and Aire-deficient (filled symbols) mice after birth were plotted. Measurement for many Aire-deficient NOD mice was terminated around 15–17 weeks after birth because of their lethal phenotypes. (B) Growth retardation of Aire-deficient NOD mice. Littermates of 7-week-old males are shown. (C) Pancreatic mass was absent from many Aire-deficient NOD mice upon gross inspection. Instead, many small white patches were scattered throughout the thin and lucent adipose tissues. The square areas marked with white and black lines are enlarged and shown in the bottom left and bottom right panels, respectively. An arrow (in the top right panel) indicates an enlarged pancreatic lymph node. Original magnification, ×1.2. Ki, kidney; P, pancreas; Sp, spleen; St, stomach.