CFTR is required for PKA-regulated ATP sensitivity of Kir1.1 potassium channels in mouse kidney
J. Clin. Invest. Ming Lu, et al. 116:797 doi:10.1172/JCI26961 [Go to this article.]

Figure 5
Glibenclamide sensitivity of ROMK in inside-out patches from TAL apical membrane of wild-type and mCFTR^–/– mice. (A) Low concentration of glibenclamide reversibly reduced ROMK channel activity with an IC₅₀ of 15 μM in wild-type mice. (B) Glibenclamide had no significant effect on ROMK channel activity at 0.2 mM (IC₅₀, 0.68 mM) in mCFTR^–/– mice. (C) Glibenclamide dose response of the normalized NPo.