CFTR is required for PKA-regulated ATP sensitivity of Kir1.1 potassium channels in mouse kidney
J. Clin. Invest. Ming Lu, et al. 116:797 doi:10.1172/JCI26961 [Go to this article.]

Figure 3
Extracellular ATP inhibits the ROMK channel in the apical membrane of TAL. Low concentration of Mg-ATP (200 μM) reversibly reduced ROMK channel activity in cell-attached patches, likely through stimulation of a P₂Y₂ receptor, in wild-type (A) and mCFTR^–/– mice (B) held at a –V of 0 mV.