CFTR is required for PKA-regulated ATP sensitivity of Kir1.1 potassium channels in mouse kidney
J. Clin. Invest. Ming Lu, et al. 116:797 doi:10.1172/JCI26961 [Go to this article.]

Figure 1
Electrophysiological characteristics of ROMK channels in the apical membrane of mouse cortical TAL. Representative single-channel recordings of a cftr^tm1Unc-cftr^hFABP transgenic mouse (mCFTR^–/–; A) and a cftr^tm1Kth transgenic mouse (ΔF508-CFTR; B) ROMK channel in an inside-out patch configuration at different –V: 0, –20, –40, –60 and –80 mV (left). Maximally open state (O) and complete channel closure (C) are indicated. Single–channel I-V curve (A, upper right) shows slight inward rectification with a slope conductance of 32.1 pS. The ΔF508-CFTR mouse had similar electrophysiological characteristics to the mCFTR^–/– mouse (lower right). I(pA), current in picoamperes.