Senescence-associated phenotypes in Akita diabetic mice are enhanced by absence of bradykinin B2 receptors
J. Clin. Invest. Masao Kakoki, et al. 116:1302 doi:10.1172/JCI26958 [Go to this article.]

Figure 3
Kidneys of 12-month-old mice of the 4 genotypes. (A) PAS-stained kidneys. There were numerous intracellular pigmented vacuoles in the cytoplasm of the proximal tubular epithelial cells of the doubly mutant mouse. Pigmented vacuoles were present to a lesser degree in the proximal tubules of the Akita diabetic mouse with intact B2 receptors but were absent in the B2 receptor–null and WT nondiabetic mice. The areas selected for imaging are representative of each genotype. (B) Transmission electron micrograph of a renal proximal tubule cell from a doubly mutant mouse. Note the numerous lipid debris–containing phagolysosomes with focal laminations (arrows). Scale bars: 10 μm (A), 1 μm (B).