Senescence-associated phenotypes in Akita diabetic mice are enhanced by absence of bradykinin B2 receptors
J. Clin. Invest. Masao Kakoki, et al. 116:1302 doi:10.1172/JCI26958 [Go to this article.]

Figure 2
Testes of 12-month-old mice of the 4 genotypes. (A) Low-magnification H&E-stained testes. Loss of spermatogonia was severe in the double mutant. Some spermatic cords in the Akita diabetic mouse were aspermic (outside the dotted red line). The testes of the B2 receptor–null and WT mice had normal spermatic cords. (B) High-magnification H&E-stained testes of 12-month-old mice. There were numerous intracellular pigmented vacuoles in the Leydig cells of the doubly mutant mouse. Pigmented vacuoles in Leydig cells were also present to a somewhat lesser degree in the Akita diabetic mouse. They were sparse in the B2-null mouse, and absent in the WT mouse. The areas selected for imaging in A and B are representative of each genotype. Scale bars: 100 μm (A), 10 μm (B).