Relating TCR-peptide-MHC affinity to immunogenicity for the design of tumor vaccines
J. Clin. Invest. Rachel H. McMahan, et al. 116:2543 doi:10.1172/JCI26936 [Go to this article.]

Figure 2
Mimotopes potently activate the T cell clone. The T cell clone was cultured with increasing concentrations of the AH1 peptide, mimotopes, or the negative control β-gal peptide. (A) Production of IFN-γ, as determined by ELISA, from the T cell clone in response to incubation for 24 hours with the indicated peptide. (B) After 24 hours, ³H-thymidine was added to the cultures, and ³H-thymidine incorporation was measured at 48 hours. Data are representative of 2 experiments per peptide, and each data point was performed in triplicate and averaged. ND, no data (EC₅₀ was too low to be determined).