Reprogramming of antiviral T cells prevents inactivation and restores T cell activity during persistent viral infection
J. Clin. Invest. David G. Brooks, et al. 116:1675 doi:10.1172/JCI26856 [Go to this article.]

Figure 4
Decreased infection of DCs and long-term control of viral replication following early antiviral therapy. (A) Serum viral titers were determined on the indicated days from LCMV Arm– or Cl 13–infected mice that were either left untreated or treated on days 1–8 with ribavirin (Rb). Data are expressed as plaque-forming units per milliliter of serum. The dashed line indicates the lower limit of detection (250 PFU/ml serum). Each circle represents a single animal. *Statistically significant difference of P < 0.03. (B) Splenic DCs, B cells, and macrophages were sorted on day 9 from LCMV Cl 13–infected animals that were either left untreated (gray bars) or treated with ribavirin (black bars). The frequency of cells producing infectious virus in each sorted population was determined by an infectious center assay. Data represent 2 experiments containing pools from 4 mice per group. Tx, treatment.