Kidney stone disease
J. Clin. Invest. Fredric L. Coe, et al. 115:2598 doi:10.1172/JCI26662 [Go to this article.]

Figure 2
Accumulation of interstitial crystal deposits as seen in light and TEM images in a papillary biopsy from an idiopathic CaOx SF. (A) Light microscopy reveals extensive accumulation of crystalline deposits (green arrow) shown around the Henle loops and nearby vascular bundles and inner medullary CDs. This progressive accumulation of crystalline material in the interstitium results in the formation of incomplete to complete cuffs of plaque. (B) TEM reveals a normal thin Henle loop surrounded by a complete cuff of interstitial plaque. (C) TEM shows a site of plaque located in the interstitial space, away from a tubular wall. Note that single crystal deposits appear embedded in a sea of matrix. Magnification: ×1,500 (A); ×13,000 (B); ×13,000 (C). A reprinted from ref. 19. B reprinted with permission from Urological Research (123). C reprinted with permission from Kidney International (21).