Transcription factor T-bet regulates inflammatory arthritis through its function in dendritic cells
J. Clin. Invest. Jingsong Wang, et al. 116:414 doi:10.1172/JCI26631 [Go to this article.]

Figure 2
CAIA can be induced in both WT and RAG2^–/– mice and is diminished in the absence of T-bet. Seven-week-old BALB/c mice (WT) and (A) RAG2^–/– mice on BALB/c background (RAG2 KO), (B) T-bet^–/– mice (T-bet KO), and (C) RAG2^–/–T-bet^–/– DKO mice (RAG2/T-bet DKO) were subjected to arthritis induction. Clinical signs of inflammation (A–C) and paw swelling (D) were scored and plotted at different time points as indicated. The values are expressed as mean ± SEM. Each group consists of 4 mice. The results shown are representative of 3 to 5 separate experiments. Unpaired Student’s t tests were performed on days 6 and 12 after arthritis induction. *P > 0.3; **P < 0.05; ^#P < 0.02; ^##P < 0.002; ^†P < 0.001; ^††P < 0.001.