Ca²⁺/calmodulin-dependent protein kinase II regulates cardiac Na⁺ channels
J. Clin. Invest. Stefan Wagner, et al. 116:3127 doi:10.1172/JCI26620 [Go to this article.]

Figure 2
E_m dependence of I_Na activation in rabbit myocytes (10 mM [Na⁺]_o). (A) Current-voltage relation (I-V) for CaMKIIδ_c versus β-gal myocytes. (B) I_Na activation curve, with relative conductance derived from maximal chord conductance and reversal potential (E_rev) for each I-V, and peak I_Na/(E_m – E_rev). The resulting conductance was normalized to the maximal chord conductance (usually between –10 and 0 mV). CaMKIIδ_C had no effect on voltage for half-activation V_1/2 or slope factor k (mV). Maximal I_Na was –4.3 ± 0.2 nA and –49.8 ± 2.4 pA/pF (C_m, 88.2 ± 5.7 pF) for CaMKIIδ_c versus –4.1 ± 0.5 nA and –42.8 ± 4.4 pA/pF (C_m, 103.8 ± 17.7 pF) for β-gal (P = NS).