Mechanisms of sudden cardiac death
J. Clin. Invest. Michael Rubart, et al. 115:2305 doi:10.1172/JCI26381 [Go to this article.]

Figure 2
Schematic illustration of intracellular Ca²⁺ cycling and associated second messenger pathways in cardiomyocytes (figure modified from ref. 84). AC, adenylyl cyclase; α, G protein subunit α; α-receptor, α-adrenergic receptor; β, G protein subunit β; β-receptor, β-adrenergic receptor; γ, G protein subunit γ; LTCC, L-type Ca²⁺ channel; CAMKII, Ca²⁺-calmodulin kinase II; I-1, inhibitor 1; NCX, Na⁺/Ca²⁺ exchanger; P, phosphate group; PLC, phospholipase C; PLN, phospholamban; PP1, protein phosphatase 1; PP2A, protein phosphatase 2A; SERCA2a, SR Ca²⁺-ATPase isoform 2a; T-tubule, transverse tubule.