Regulation of glucagon secretion by glucose transporter type 2 (glut2) and astrocyte-dependent glucose sensors
J. Clin. Invest. Nell Marty, et al. 115:3545 doi:10.1172/JCI26309 [Go to this article.]

Figure 6
Normal glucagon secretion in response to i.c.v. injection of 2-DG in Sv129, B6D2F1, and Sv129xB6D2F1 mice. Plasma glucagon levels measured 30 minutes after i.c.v. injection of NaCl or 2-DG in Sv129 (A), B6D2F1 (B), and Sv129xB6D2F1 (C) mice. 2-DG induced a strong increase in plasma glucagon levels in each mouse strain. Data are indicated as mean ± SD; n = 6–7 for each data point. *P < 0.05 and **P < 0.01 for comparison between NaCl- and 2-DG–injected groups (Student’s t test).