CD4⁺ T cell–independent DNA vaccination against opportunistic infections
J. Clin. Invest. Mingquan Zheng, et al. 115:3536 doi:10.1172/JCI26306 [Go to this article.]

Figure 5
Humoral responses after pKexin or pKexin/CD40L DNA vaccination. (A) Schema of PC Kexin vaccination protocol. DNA vectors used were pKexin, pKexin/CD40L, pBUDCE4 (as empty vector), or pCD40L. (B) Anti-PC IgG1 and IgG2a responses after pKexin or pKexin/CD40L after intramuscular DNA immunization in CD4-depleted and CD4-replete mice. n = 6–8. All data are mean titer ± SEM. *P < 0.05 compared with control. (C) Anti-PC IgG1 and IgG2a responses after pKexin or pKexin/CD40L after intramuscular DNA immunization in CD4^–/– and CD4^+/+ mice. n = 4–6. All data are mean titer ± SEM. **P < 0.05 compared with CD4^+/+ mice or pKexin/CD40L in CD4^–/– mice. A line denotes the limit of detection in the ELISA.